Vitamin K deficiency is rare among humans and most other animal species. This is due to the wide occurrence of vitamin K in plant and animal foods and to the significant microbial synthesis of the vitamin that occurs in the intestines. Vitamin K deficiencies can be caused by a variety of factors. These include:
*Not consuming enough vitamin K from one's diet can contribute to a deficiency. Dietary vitamin K is highest in leafy green vegetables such as lettuce, kale, broccoli and collard greens.
*A diet with high intakes of salicylates can block vitamin K. Salicylates are found in foods such as nuts, fruits, spices and mints. Aspirin is a salicylate. Blocking vitamin K is why aspirin can "thin" the blood - it basically keeps blood from coagulating. This is why too much aspirin can cause stomach and intestinal bleeding.
*Candida (systemic yeast) infections have been linked to vitamin K deficiencies. An overgrowth of Candida albicans or other kinds of yeast can crowd out the helpful bacteria in the digestive tract that make vitamin K. People who eat a lot of sugary foods, an unusually high proportion of alkaline foods and/or take antibiotics tend to be at high risk for Candida infections.
*The vitamin is lipid soluble and is absorbed primarily in the small intestine. A healthy patient usually has a 30-day body store. Vitamin K deficiency occurs with anatomic lesions that bypass the small intestine, malabsorption, intrahepatic or biliary obstruction, hepatic disease, and rarely with inadequate intake.
*Megadoses of vitamins A and E counteract the actions of vitamin K. Vitamin A appears to hamper intestinal absorption of vitamin K and excess vitamin E seems to decrease the vitamin K dependent clotting factor, thus promoting bleeding.
*A variety of antibiotics interferes with intestinal bacteria growth and can impair vitamin K synthesize or interferes with intracellular role of vitamin K.
*The most common cause of fully functional vitamin K deficiency is the therapeutic use of oral anticoagulant drugs of the coumarin family, such as warfarin. Warfarin blocks the action of vitamin K. In turn, vitamin K blocks the action of anticoagulants. That could block blood vessels leading to the heart or brain.
*The bacteria that synthesize vitamin K thrive in an acidic digestive environment. Antacids, if taken in sufficient quantity, may cause a vitamin K deficiency, as well as irritable bowel syndrome and various nutritional deficiencies, because they neutralize the hydrochloric acid in a person's stomach. Hydrochloric acid is needed to digest food and create the acidic environment in which the beneficial bacteria thrive.
*Vitamin K is furnished by dietary intake of plant foods and synthesis by intestinal flora. Some drugs disrupt vitamin K’s synthesis and action in the body: antibiotics kill the vitamin K-producing bacteria in the intestine, and anticoagulant drugs interfere with vitamin K metabolism and activity. When vitamin K deficiency does occur, it can be fatal.
Deficiency of vitamin K
